Acidaemia and salicylate poisoning in adults.

Accidental methyl salicylate poisoning in two adults.

Methyl salicylate (MS) is widely available as a component in many over-the-counter brands of ointments, lotions, liniments and medicated oils intended for topical application [1]. Among the most potent forms of methyl salicylate is oil of wintergreen (98% MS). Salicylate ointment has a very high concentration of MS. One teaspoon contains 7000 mg MS, equivalent to 90 baby aspirin tablets.We repo...

Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches

The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over t...

Plasma salicylate levels in acute poisoning in adults.

Diuresis or urinary alkalinisation for salicylate poisoning?

Forty-four adults with aspirin poisoning were treated with oral fluids only, standard forced alkaline diuresis, forced diuresis alone, or sodium bicarbonate (alkali) alone. Alkali alone was at least as effective and possibly more effective than forced alkaline diuresis in enhancing salicylate removal. Unlike the diuresis regimens it did not cause fluid retention or biochemical disturbances. The...

An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose.

OBJECTIVE To develop a flowchart to be used as a tool to guide clinicians step by step through the management of salicylate poisoning. METHODS A comprehensive literature search was carried out. RESULTS The evidence base was used to develop a management flowchart that guides the clinician through the three main steps in caring for the patient with salicylate poisoning: preventing further abs...